Penfield High School offers a range of educational courses for students in grades 9 through 12. Its academic programs include instruction in English, science, history and mathematics. The school also provides physical education, dance, music, theatre and visual arts classes. Penfield High School operates a student council, youth group, math league, and chess, debate, environmental, Japanese, jewelry, media, ski and media clubs. It additionally offers membership opportunities for students to participate in the National Honor Society programs. The school operates a career center that provides technical training and job skills development opportunities. Penfield High School administers a parent-teacher-student association that sponsors several educational activities. The school is governed by the Penfield Central School District.