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Eden Prairie / Minnesota / United States
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Corporate Technologies LLC is a provider of managed information technology solutions for businesses and institutions in Minnesota, North Dakota, Idaho, Southern California, West Michigan and New Jersey. The company offers a wide range of services, including staffing, computer networking solutions, systems integration and consulting, Voice Over Internet Protocol and unified communications systems among others. In addition, it provides Technology Advantage, a unique solution that provides remote monitoring and maintenance, help desk services and on-site tech support for small, as well as medium sized business. Some of the partners of the company include Microsoft Corporation, Hewlett-Packard Development Company, L.P., Cisco Systems Inc., Symantec and IBM.
Kittanning / Pennsylvania / United States
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Sylvan is a global leader in fungal technology and one of the worlds largest producers and distributors of mushroom spawn. Sylvan has differentiated its spawn products through production technology, quality assurance, technical service to mushroom growers and ongoing research and development. The company s products include spawn for agaricus mushroom strains and for other cultivated mushrooms like the Pleurotus and Shiitake. Sylvans unique spawn-making technology is centered around its ability to grow microorganisms on solid-substrates in a sterile environment. The spawn is consistent worldwide because of the company s two technologically advanced inoculum production facilities in Europe and North America.
Carlsbad / California / United States
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Applied Spectral Imaging develops and markets state-of-the-art imaging systems for the life sciences and health care markets. The company commercialized its patented technology for both the qualitative and quantitative analysis of light in the visible spectrum. The company is also a leading provider of cytogenetics systems to prestigious clinical and research labs throughout the world. Its CytoLabView suite offers a complete solution for all imaging needs in the lab and includes applications for karyotyping, FISH, CGH, multi-color karyotyping and general spectral imaging. In addition, the company continues to develop products to expand its competitive offerings in the market to include its new automatic scanning platform, ScanView. The company was founded in 1993.
Bothell / Washington / United States
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Seattle Genetics is a biotechnology company focused on developing monoclonal antibody-based therapeutics for cancer and immunologic diseases. The targeting ability of mAbs provides a means to identify and kill cancer cells while limiting damage to normal tissue. Additionally, the company has more than 130 employees and is located in a high-technology campus in Bothell, Wash. Seattle Genetics was founded in 1997 and is a publicly traded company listed on the NASDAQ under the symbol SGEN.
South San Francisco / California / United States
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Since 1997, Actelion Pharmaceuticals has been researching, developing and marketing new treatments for a variety of critical healthcare needs. The Switzerland-based company, which has a subsidiary in the Sierra Point area of South San Francisco, caters to a global market and works on medications and treatments for a range of diseases that are often not highly publicized, like pulminary arterial hypertension. This location is a research and development facility and is not open to the public, but contact information can be found on Actelion's website (see link above).

Emeryville / California / United States
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Currently, Milagen manufactures and commercializes tissue-based immunodiagnostic products as aid to the pathologist. Milagen offers its product line directly to end-users, and in partnership with diagnostic companies and clinical reference laboratories.
South San Francisco / California / United States
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Targacept is a biopharmaceutical company engaged in the design, discovery and development of a new class of drugs to treat diseases and disorders of the central nervous system. It is a leader in the field of neuronal nicotinic acetylcholine receptor chemistry and biology. NNRs are found on nerve cells throughout the nervous system and serve as key regulators of nervous system activity. Targacept s product candidates are designed to selectively target specific NNR subtypes and promote therapeutic effects and limit adverse side effects. Targacept has product candidates in clinical development for cognitive impairment, including Alzheimer s disease and age-associated memory impairment, pain and depression. From 1997 to 2000, Targacept was a subsidiary of R. J. Reynolds Tobacco Company. During this time, the company s investigations into the biological effects of nicotine suggested a role for NNRs in the treatment of human disease and led to the creation of Targacept.
Modesto / California / United States
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Harris Moran Seed Company breeds the best and forgets the rest. The company breeds vegetable varieties designed to boost yield, reduce chemical inputs and increase freshness, flavor and quality. Its seed varieties include beans, beets, broccoli, cabbage, carrots, cauliflower, cilantro, corn, cucumbers, eggplant, leek, lettuce, melons, peppers, pumpkins, radicchio, radishes, squashes, tomatoes and watermelons. The company concentrates on four plant-breeding basics: yield, eating quality, adaptability and disease resistance. Its integration into Groupe Limagrain allows the company to tap into plant pathology expertise, biotechnology, post harvest fruit physiology and more diverse germplasm bases, which allows Harris Moran to create new and better varieties of seeds that feature disease protection built-in, not added on. Harris Moran Seed Company is in Modesto, Calif.
New York / New York / United States
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SIGA Technologies applies microbial genomics to the design and development of novel products that prevent and treat infectious diseases, as well as defend against biological warfare agents. With technology platforms in both vaccines and antibiotics, the company s platform technologies include a vaccine delivery system that activates the immune system at the body s mucosal surfaces in order to prevent infection at the earliest possible stage, a surface protein expression system for the cost-effective production of proteins, biothreat rapid response therapeutics that can be rapidly designed on demand for any biological pathogen and virus counterstrike capability technology that can be used to develop safe and effective antivirals by targeting the proteinases which are encoded within all viruses. SIGA Technologies is headquartered in New York.
Bohemia / New York / United States
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Our mission at Thermo Fisher is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity.
Irvine / California / United States
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Advanced BioCatalytics Corporation is a biotechnology business that specializes in cleaners, water treatment and more. It uses the latest technologies to find eco-friendly techniques for energy consumption. The company uses safe products for water cleanup, including biodegradable and non-flammable products.

Colorado Springs / Colorado / United States
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Our mission at Thermo Fisher is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity.
Camarillo / California / United States
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Founded as Integrity Biosolution in 2003, Integrity Bio Inc. has been offering formulation development services since its inception. The company Integrity Bio Inc. has become one of the largest designing and constructing Good Manufacturing Practices (GMP)-compliant parenteral manufacturing facilities. The company develops, transfers, qualifies and validates many assays from Total Organic Carbon (TOC) to High Performance Liquid Chromatography (HPLC), and beyond. Its core business of formulation development has successfully served both early-stage companies and several of the worlds largest biotechnology, pharmaceutical and medical device companies. The contract manufacturing services offered by Integrity Bio Inc. are formulation development, GMP fill-and-finish, stability studies and testing.
Incline Village / Nevada / United States
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PDL BioPharma is one of the recognized leaders in the discovery and development of humanized monoclonal antibodies for the treatment of disease. The company s patented humanization technology platform is one of the most-widely validated antibody technologies in the industry. With seven-marketed antibody products already licensed under its humanization patents and at least 40 additional humanized antibodies in clinical trials, PDL BioPharma believes the promise of its humanization technology is well on the way to becoming fully realized. The company leveraged its expertise in antibody humanization to become a fully integrated biopharmaceutical company that creates, develops, manufactures and, in North America, markets proprietary biopharmaceutical products. Its most advanced clinical-stage program is visilizumab for the treatment of severe refractory ulcerative colitis. The company, which maintains operations in Fremont, Calif., also has antibodies in development for asthma and cancer. PDL trades on NASDAQ under the symbol PDLI.